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Promoter Hypermethylation Is the Predominant Mechanism in <i>hMLH1</i> and <i>hMSH2</i> Deregulation and Is a Poor Prognostic Factor in Nonsmoking Lung Cancer

1 Aug 2005

Abstract excerpt

PURPOSE AND EXPERIMENTAL DESIGN: The etiologic association and prognostic significance of mismatch repair gene/protein alterations have never been examined in nonsmoking lung cancer. Therefore, we investigated protein expression and promoter hypermethylation of hMLH1 and hMSH2 genes in the tumor specimens from 105 nonsmoking female non-small cell lung cancer (NSCLC) patients. Immunohistochemistry and restriction...

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PMID: 16061855
DOI: 10.1158/1078-0432.ccr-05-0601

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