Article
Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse.
The Journal of biological chemistry - 6 Feb 2009
Pedram Ali, Razandi Mahnaz, Kim Jin K, O'Mahony Fiona, Lee Eva Yhp, Luderer Ulrike, Levin Ellis R
Abstract excerpt
Estrogen receptors (ERs) alpha and beta exist as nuclear, cytoplasmic, and membrane cellular pools in a wide variety of organs. The relative contributions of each ERalpha pool to in vivo phenotypes resulting from estrogen signaling have not been determined. To address this, we generated a transgenic mouse expressing only a functional E domain of ERalpha at the plasma membrane (MOER). Cells isolated from many...
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