Dominant negative Tax double mutants as molecular inhibitors for w.t. Tax gene functions.

Abstract excerpt

Tax plays a key role in HTLV-1 pathogenicity, partly due to its capacity of constitutive NF-kappaB activation. Delta58Tax does not translocate to the nucleus and traps w.t. Tax molecules in the cytoplasm but still retains the cytoplasmic NF-kappaB activation ability. Therefore, it enhances the w.t. Tax activation of NF-kappaB when co-expressed at lower level than w.t. Tax. However, the double mutants Delta58Tax...

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