Article
Identification of new genetic risk factors for prostate cancer.
Asian journal of andrology - 1 Jan 2009
Guy Michelle, Kote-Jarai Zsofia, Giles Graham G, Al Olama Ali Amin, Jugurnauth Sarah K, Mulholland Shani, Leongamornlert Daniel A, Edwards Stephen M, Morrison Jonathan, Field Helen I, Southey Melissa C, Severi Gianluca, Donovan Jenny L, Hamdy Freddie C, Dearnaley David P, Muir Kenneth R, Smith Charmaine, Bagnato Melisa, Ardern-Jones Audrey T, Hall Amanda L, O'Brien Lynne T, Gehr-Swain Beatrice N, Wilkinson Rosemary A, Cox Angela, Lewis Sarah, Brown Paul M, Jhavar Sameer G, Tymrakiewicz Malgorzata, Lophatananon Artitaya, Bryant Sarah L, Horwich Alan, Huddart Robert A, Khoo Vincent S, Parker Christopher C, Woodhouse Christopher J, Thompson Alan, Christmas Tim, Ogden Chris, Fisher Cyril, Jameson Charles, Cooper Colin S, English Dallas R, Hopper John L, Neal David E, Easton Douglas F, Eeles Rosalind A
Abstract excerpt
There is evidence that a substantial part of genetic predisposition to prostate cancer (PCa) may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.