Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations.

Neoplasia (New York, N.Y.) - 1 Dec 2008

Sangha Navneet, Wu Rong, Kuick Rork, Powers Scott, Mu David, Fiander Diane, Yuen Kit, Katabuchi Hidetaka, Tashiro Hironori, Fearon Eric R, Cho Kathleen R

Abstract excerpt

Ovarian serous carcinoma (OSC) is the most common and lethal histologic type of ovarian epithelial malignancy. Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to DNA, Complementary
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Genes, p53

Share to Neurofibromin 1

Share to Ovarian Neoplasms

Share to Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 19048115
DOI: 10.1593/neo.08784
PMCID: PMC2586687

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19048115-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations.PMID 19048115Read ↗

Integrative Genomic and Functional Analysis Reveals NF1 Loss as a Modifier of DNA Damage and Replication Stress Responses in Ovarian Cancer.Semantic proximity Read ↗

Integrated genomic analyses of ovarian carcinoma.Semantic proximity Read ↗

NOTCH2 gene mutation and gamma-secretase inhibitor in mediating the malignancy of ovarian cancer.Semantic proximity Read ↗

Biallelic NF1 inactivation in high grade serous ovarian cancers from patients with neurofibromatosis type 1Semantic proximity Read ↗

NGS Analysis Confirms Common TP53 and RB1 Mutations, and Suggests MYC Amplification in Ocular Adnexal Sebaceous Carcinomas.Semantic proximity Read ↗

NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancerSemantic proximity Read ↗

Upregulation of fibronectin following loss of p53 function is a poor prognostic factor in ovarian carcinoma with a unique immunophenotype.Semantic proximity Read ↗

EIF1AX and NRAS Mutations Co-occur and Cooperate in Low-Grade Serous Ovarian Carcinomas.Semantic proximity Read ↗

Neoplasms Associated with Germline and Somatic NF1 Gene MutationsSemantic proximity Read ↗

<i>NF1</i> deficiency correlates with estrogen receptor signaling and diminished survival in breast cancerSemantic proximity Read ↗

Upregulation of fibronectin following loss of p53 function is a poor prognostic factor in ovarian carcinoma with a unique immunophenotypeSemantic proximity Read ↗

Frequent CCNE1 amplification in endometrial intraepithelial carcinoma and uterine serous carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.