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Article

NGS Analysis Confirms Common TP53 and RB1 Mutations, and Suggests MYC Amplification in Ocular Adnexal Sebaceous Carcinomas.

International journal of molecular sciences - 6 Aug 2021

Peterson Cornelia, Moore Robert, Hicks Jessica L, Morsberger Laura A, De Marzo Angelo M, Zou Ying, Eberhart Charles G, Campbell Ashley A

Abstract excerpt

Ocular adnexal (OA) sebaceous carcinomas generally demonstrate more aggressive clinical and histopathological phenotypes than extraocular cases, but the molecular drivers implicated in their oncogenesis remain poorly defined. A retrospective review of surgical and ocular pathology archives identified eleven primary resection specimens of OA sebaceous carcinomas with adequate tissue for molecular analysis; two...

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PMID: 34445161
DOI: 10.3390/ijms22168454
PMCID: PMC8395148

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