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Article

The use of GEM models for experimental cancer therapeutics

26 Sept 2008

Abstract excerpt

The proposal of new therapeutic strategies for cancer patients has been greatly facilitated by our deepening knowledge of the molecular and cellular etiology of neoplasia. However, the absence of effective in vivo systems that accurately predict clinical efficacy has hindered drug development in oncology. Here, we will briefly discuss the potential advantage of genetically engineered tumor-prone mice compared...

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PMID: 19048065
DOI: 10.1242/dmm.000570

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