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Genetically Engineered Models Have Advantages over Xenografts for Preclinical Studies

1 Apr 2006

Abstract excerpt

Mouse models of human cancer are valuable tools for cancer research. Although xenografts and genetically engineered models (GEMs) possess limitations as well as advantages, each system plays a significant role in preclinical testing. Tumor xenografts are easy to use, relatively inexpensive, and reproducible. The main drawback of xenografts is that the genetics and histology of the tumors are frequently not...

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PMID: 16585152
DOI: 10.1158/0008-5472.can-05-3827

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