Article
Mitoferrin is essential for erythroid iron assimilation.
Nature - 2 Mar 2006
Shaw George C, Cope John J, Li Liangtao, Corson Kenneth, Hersey Candace, Ackermann Gabriele E, Gwynn Babette, Lambert Amy J, Wingert Rebecca A, Traver David, Trede Nikolaus S, Barut Bruce A, Zhou Yi, Minet Emmanuel, Donovan Adriana, Brownlie Alison, Balzan Rena, Weiss Mitchell J, Peters Luanne L, Kaplan Jerry, Zon Leonard I, Paw Barry H
Abstract excerpt
Iron has a fundamental role in many metabolic processes, including electron transport, deoxyribonucleotide synthesis, oxygen transport and many essential redox reactions involving haemoproteins and Fe-S cluster proteins. Defective iron homeostasis results in either iron deficiency or iron overload. Precise regulation of iron transport in mitochondria is essential for haem biosynthesis, haemoglobin production and...
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