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Article

Site-directed mutagenesis of dicarboxylic acids near the active site of Bacillus cereus 5/B/6 beta-lactamase II.

The Biochemical journal - 1 Jun 1991

Lim H M, Iyer R K, Pène J J

Abstract excerpt

An amino acid residue functioning as a general base has been proposed to assist in the hydrolysis of beta-lactam antibiotics by the zinc-containing Bacillus cereus beta-lactamase II [Bicknell & Waley (1985) Biochemistry 24, 6876-6887]. Oligonucleotide-directed mutagenesis of cloned Bacillus cereus 5/B/6 beta-lactamase II was used in an 'in vivo' study to investigate the role of carboxy-group-containing amino...

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Identifiers

PMID: 1904717
DOI: 10.1042/bj2760401
PMCID: PMC1151105

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