Article
The conserved methionine residue of the metzincins: a site-directed mutagenesis study.
Journal of molecular biology - 23 Nov 2001
Hege T, Baumann U
Abstract excerpt
The metalloprotease clan of the metzincins derive their name from the presence of a conserved methionine residue that is located on the C-terminal side of the zinc-binding consensus sequence HEXXHXXGXXH. This methionine residue is located in a rather divergent part of the primary sequence but is structurally very well conserved. It is located under the pyramidal base of the three histidine residues that...
Topics
- Amino Acid Substitution
- Binding Sites
- Consensus Sequence
- Conserved Sequence
- Crystallization
- Crystallography, X-Ray
- Dickeya chrysanthemi
- Enzyme Stability
- Glutamic Acid
- Histidine
- Kinetics