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Article

Evaluation of the mutagenic effects of myosmine in human lymphocytes using the HPRT gene mutation assay.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Jan 2009

Havla J B, Hill C E, Abdel-Rahman S Z, Richter E

Abstract excerpt

The minor tobacco alkaloid myosmine is implicated in DNA damage through pyridyloxobutylation similar to the tobacco-specific nitrosamines (TSNA). In contrast to TSNA, occurrence of myosmine is not restricted to tobacco. Myosmine is genotoxic to human cells in the comet assay. In this study, the mutagenic effect of myosmine was evaluated using the cloning hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene...

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Source

Identifiers

PMID: 19041922
DOI: 10.1016/j.fct.2008.11.008

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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