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Article

Virtual tissue engineering of the human atrium: modelling pharmacological actions on atrial arrhythmogenesis.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 16 Jul 2012

Aslanidi Oleg V, Al-Owais Moza, Benson Alan P, Colman Michael, Garratt Clifford J, Gilbert Stephen H, Greenwood John P, Holden Arun V, Kharche Sanjay, Kinnell Elizabeth, Pervolaraki Eleftheria, Plein Sven, Stott Jonathan, Zhang Henggui

Abstract excerpt

Computational models of human atrial cells, tissues and atria have been developed. Cell models, for atrial wall, crista terminalis, appendage, Bachmann's bundle and pectinate myocytes are characterised by action potentials, ionic currents and action potential duration (APD) restitution. The principal effect of the ion channel remodelling of persistent atrial fibrillation (AF), and a mutation producing familial...

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Identifiers

PMID: 21888968
DOI: 10.1016/j.ejps.2011.08.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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