Article
Association of a polymorphism in the intron 7 of the SREBF1 gene with osteonecrosis of the femoral head in Koreans.
Annals of human genetics - 1 Jan 2009
Lee H-J, Choi S-J, Hong J M, Lee W K, Baek J-I, Kim S-Y, Park E K, Kim S-Y, Kim T-H, Kim U-K
Abstract excerpt
Reduction or disruption of the blood supply to the bone is involved in the pathogenesis of osteonecrosis of the femoral head (ONFH). An altered lipid metabolism is one of the major risk factors for ONFH. Sterol regulatory element binding protein, SREBF1 activates genes regulating lipid biosynthes...
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