Article
Association study of hypoxia inducible factor 1alpha (HIF1alpha) with osteonecrosis of femoral head in a Korean population.
Osteoarthritis and cartilage - 1 Jun 2007
Hong J Min, Kim T-H, Chae S-C, Koo K-H, Lee Y Jong, Park E Kyun, Choi J-Y, Ryoo H-M, Kim S-Y
Abstract excerpt
OBJECTIVE: Disruption of the vascular supply to the bone and subsequent hypoxia has been implicated in the pathogenesis of osteonecrosis (ON) of the femoral head (ONFH). To evaluate the genetic effect of HIF1alpha, a key transcription factor in controlling hypoxia condition, on ONFH, we analyzed HIF1alpha polymorphism and its genetic association with ONFH. METHODS: We directly sequenced the HIF1alpha gene in 24...
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