Article
Association of SREBP2 gene polymorphisms with the risk of osteonecrosis of the femoral head relates to gene expression and lipid metabolism disorders.
Molecular medicine reports - 1 Nov 2017
Song Yang, Du Zhenwu, Chen Bingpeng, Ren Ming, Yang Qiwei, Sui Yujie, Wang Qingyu, Wang Ao, Zhao Haiyue, Qin Yanguo, Zhang Guizhen
Abstract excerpt
Although lipid metabolism disorders have been recognized as a primary factor of osteonecrosis of the femoral head (ONFH), the molecular pathogenesis remains unclear. Sterol regulatory element‑binding protein 2 (SREBP2) specifically regulates cholesterol and fatty acid metabolism to maintain lipid homeostasis. To explore the roles of the SREBP2 gene in the development of ONFH, the authors analyzed the gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.