Article
Association of interleukin 23 receptor variants with psoriatic arthritis.
The Journal of rheumatology - 1 Jan 2009
Rahman Proton, Inman Robert D, Maksymowych Walter P, Reeve Jeff P, Peddle Lynette, Gladman Dafna D
Abstract excerpt
OBJECTIVE: A recent genome-wide pooling study noted a significant association of interleukin 23 receptor (IL-23R) and psoriasis. Overxpression of IL-23 has been detected in lesional psoriatic skin, and induces epidermal proliferation. Given the interplay between psoriasis and PsA, we examined the association of IL-23R variants in 2 independent Canadian Caucasian cohorts of patients with psoriatic arthritis (PsA)....
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