Article
Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Aug 2009
Hollis-Moffatt J E, Merriman M E, Rodger R A, Rowley K A, Chapman P T, Dalbeth N, Gow P J, Harrison A A, Highton J, Jones P B B, O'Donnell J L, Stamp L K, Merriman T R
Abstract excerpt
OBJECTIVE: The rare allele of a non-synonymous interleukin 23 receptor (IL23R) single nucleotide polymorphism (SNP) rs11209026 (p.Arg381Gln) confers strong protection against Crohn disease (CD) and psoriasis. Other IL23R variants also exhibit association with CD, genetically independent of rs11209026. In rheumatoid arthritis (RA), IL23 is an important determinant of the production of IL17A, a cytokine of...
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