Article
Genetic interactions among ZDS1,2, CDC37, and protein kinase CK2 in Saccharomyces cerevisiae.
FEBS letters - 20 Nov 2003
Bandhakavi Sricharan, McCann Richard O, Hanna David E, Glover Claiborne V C
Abstract excerpt
We report here the identification of the homologous gene pair ZDS1,2 as multicopy suppressors of a temperature-sensitive allele (cka2-13(ts)) of the CKA2 gene encoding the alpha' catalytic subunit of protein kinase CK2. Overexpression of ZDS1,2 suppressed the temperature sensitivity, geldanamycin (GA) sensitivity, slow growth, and flocculation of multiple cka2 alleles and enhanced CK2 activity in vivo toward a...
Topics
- Adaptor Proteins, Signal Transducing
- Alleles
- Benzoquinones
- Casein Kinase II
- Cell Cycle Proteins
- DNA-Binding Proteins
- Drosophila Proteins
- Enzyme Activation
- Genes, Suppressor
- Genotype
- Lactams, Macrocyclic
- Microscopy, Fluorescence
- Molecular Chaperones
- Phenotype