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Article

The identification of [2-(14)C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans.

Carcinogenesis - 1 Apr 1999

Malfatti M A, Kulp K S, Knize M G, Davis C, Massengill J P, Williams S, Nowell S, MacLeod S, Dingley K H, Turteltaub K W, Lang N P, Felton J S

Abstract excerpt

[2-(14)C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine ([14C]PhIP), a putative human carcinogenic heterocyclic amine found in well-done cooked meat, was administered orally to three colon cancer patients undergoing a partial colonectomy. Forty-eight to seventy-two hours prior to surgery, subjects received a 70-84 microg dose of 14C. Urine and blood were analyzed by HPLC for PhIP and PhIP metabolites....

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PMID: 10223203
DOI: 10.1093/carcin/20.4.705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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