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Article

Effect of thyroid hormone on mitochondrial properties and oxidative stress in cells from patients with mtDNA defects.

American journal of physiology. Cell physiology - 1 Feb 2009

Menzies Keir J, Robinson Brian H, Hood David A

Abstract excerpt

Mitochondrial (mt)DNA mutations contribute to various disease states characterized by low ATP production. In contrast, thyroid hormone [3,3',5-triiodothyronine (T(3))] induces mitochondrial biogenesis and enhances ATP generation within cells. To evaluate the role of T(3)-mediated mitochondrial biogenesis in patients with mtDNA mutations, three fibroblast cell lines with mtDNA mutations were evaluated, including...

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Identifiers

PMID: 19036942
DOI: 10.1152/ajpcell.00415.2007

Genes

PGC
UCP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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