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Article

Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells.

Oncogene - 7 Nov 2002

Amuthan Govindasamy, Biswas Gopa, Ananadatheerthavarada Hindupur K, Vijayasarathy Camasamudram, Shephard Henry M, Avadhani Narayan G

Abstract excerpt

We have investigated mechanisms of mitochondrial stress-induced phenotypic changes and cell invasion in tumorigenic but poorly invasive human pulmonary carcinoma A549 cells that were partly depleted of mitochondrial DNA (mtDNA). Depletion of mtDNA (genetic stress) caused a markedly lower electron transport-coupled ATP synthesis, loss of mitochondrial membrane potential, elevation of steady state [Ca(2+)](c), and...

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PMID: 12420221
DOI: 10.1038/sj.onc.1205983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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