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Thyrotropin powers human mitochondria

14 Jan 2010

Abstract excerpt

Here we demonstrate that the neuropeptide hormone thyrotropin (TSH), which controls thyroid hormone production, exerts a major nonclassical function in mitochondrial biology. Based on transcriptional, ultrastructural, immunohistochemical, and biochemical evidence, TSH up-regulates mitochondrial biogenesis and consequently activity in organ-cultured normal human epidermis in situ. Mitochondrial activity was...

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PMID: 20075194
DOI: 10.1096/fj.09-147728

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