Article
Mitochondrial Ca2+ homeostasis in human NADH:ubiquinone oxidoreductase deficiency.
Cell calcium - 1 Jul 2008
Willems Peter H G M, Valsecchi Federica, Distelmaier Felix, Verkaart Sjoerd, Visch Henk-Jan, Smeitink Jan A M, Koopman Werner J H
Abstract excerpt
NADH:ubiquinone oxidoreductase or complex I is a large multisubunit assembly of the mitochondrial inner membrane that channels high-energy electrons from metabolic NADH into the electron transport chain (ETC). Its dysfunction is associated with a range of progressive neurological disorders, often characterized by a very early onset and short devastating course. To better understand the cytopathological mechanisms...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.