Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Feb 2009

Ksiazek Krzysztof, Mikula-Pietrasik Justyna, Olijslagers Sharon, Jörres Achim, von Zglinicki Thomas, Witowski Janusz

Abstract excerpt

Both the ascites fluid-derived mesothelial cell line LP-9 and primary cultures of human omentum-derived mesothelial cells (HOMCs) are commonly used in experimental studies. However, they seem to have a different replicative potential in vitro. In the present study, we have attempted to determine the causes of this discrepancy. HOMCs were found to divide fewer times and enter senescence earlier than LP-9 cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 8-Hydroxy-2'-Deoxyguanosine
Share to beta-Galactosidase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Deoxyguanosine

Share to Lipofuscin

Share to Peritoneum

Source

Identifiers

PMID: 19036828
DOI: 10.1152/ajpregu.90451.2008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains.PMID 19036828Read ↗

Early loss of proliferative potential of human peritoneal mesothelial cells in culture: the role of p16<sup>INK4a</sup>-mediated premature senescenceSemantic proximity Read ↗

Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer CellsSemantic proximity Read ↗

Premature senescence of mesothelial cells is associated with non-telomeric DNA damageSemantic proximity Read ↗

Specificity of cytochemical and fluorescence methods of senescence-associated β-galactosidase detection for ageing driven by replication and timeSemantic proximity Read ↗

Accelerated senescence of human peritoneal mesothelial cells exposed to high glucose: the role of TGF-beta1.Semantic proximity Read ↗

Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases.Semantic proximity Read ↗

Ovarian cancer-derived ascitic fluids induce a senescence-dependent pro-cancerogenic phenotype in normal peritoneal mesothelial cells.Semantic proximity Read ↗

Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose.Semantic proximity Read ↗

Downregulation of APE1/Ref-1 Is Involved in the Senescence of Mesenchymal Stem CellsSemantic proximity Read ↗

Role of p14ARF in Replicative and Induced Senescence of Human FibroblastsSemantic proximity Read ↗

Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activitySemantic proximity Read ↗

Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.