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Article

Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity

1 Jan 1998

Abstract excerpt

We previously reported that tumor cells expressing p53 increase intracellular levels of reactive oxygen species (ROS). In this study, we described an inhibitory effect of vitamin C on replicative senescence. Vitamin C was found to inhibit p53-induced senescence in human bladder cancer EJ cells. The senescence-like phenotype (SLP) induced by p53, which showed a morphological change and an irreversible cell cycle...

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PMID: 18949386
DOI: 10.3892/ijmm_00000068

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