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Downregulation of APE1/Ref-1 Is Involved in the Senescence of Mesenchymal Stem Cells

5 Mar 2009

Abstract excerpt

The senescence of human mesenchymal stem cells (hMSCs) causes disruption of tissue and organ maintenance, and is thus an obstacle to stem cell-based therapies for disease. Although some researchers have studied changes in the characteristics of hMSCs (decreases in differentiation ability and self-renewal), comparing young and old ages, the mechanisms of stem cell senescence have not yet been defined. In this...

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PMID: 19492297
DOI: 10.1002/stem.54

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