Article
Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo.
Clinical & experimental metastasis - 1 Jan 2016
Mikuła-Pietrasik Justyna, Sosińska Patrycja, Naumowicz Eryk, Maksin Konstantin, Piotrowska Hanna, Woźniak Aldona, Szpurek Dariusz, Książek Krzysztof
Abstract excerpt
It is believed that senescent cells contribute to the progression of primary and metastatic tumors, however, the exact mechanisms of this activity remain elusive. In this report we show that senescent human peritoneal mesothelial cells (HPMCs) alter the secretory profile of ovarian cancer cells (A2780, OVCAR-3, SKOV-3) by increasing the release of four angiogenic agents: CXCL1, CXCL8, HGF, and VEGF. Proliferation...
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