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Early loss of proliferative potential of human peritoneal mesothelial cells in culture: the role of p16<sup>INK4a</sup>-mediated premature senescence

28 Oct 2005

Abstract excerpt

Much has been learned about the mechanisms underlying cellular senescence. The pathways leading to senescence appear to vary, depending on the cell type and cell culture conditions. In this respect, little is known about senescence of human peritoneal mesothelial cells (HPMC). Previous studies have significantly differed in the reported proliferative lifespan of HPMC. Therefore, in the present study, we have...

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PMID: 16254068
DOI: 10.1152/japplphysiol.01086.2005

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