Article
A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.
American journal of human genetics - 1 Apr 2002
Ranade Koustubh, Jorgenson Eric, Sheu Wayne H-H, Pei Dee, Hsiung Chao Agnes, Chiang Fu-tien, Chen Yii-der I, Pratt Richard, Olshen Richard A, Curb David, Cox David R, Botstein David, Risch Neil
Abstract excerpt
Resting heart rate is significantly associated with cardiovascular morbidity and mortality. However, the extent to which resting heart rate is genetically determined is poorly understood, and no genes have been found that contribute to variation in resting heart rate. Because signaling through the beta1 adrenergic receptor is a key determinant of cardiac function, we tested whether polymorphisms in this receptor...
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