Article
A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).
Genes & development - 1 May 1995
Steimle V, Durand B, Barras E, Zufferey M, Hadam M R, Mach B, Reith W
Abstract excerpt
Regulation of MHC class II gene expression is an essential aspect of the control of the immune response. Primary MHC class II deficiency is a genetically heterogeneous disease of gene regulation that offers the unique opportunity of a genetic approach for the identification of the functionally re...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Cell Extracts
- Cell Line
- Cell Nucleus
- Cloning, Molecular
- DNA
- DNA-Binding Proteins
- Gene Expression Regulation
- Genes, MHC Class II
- Genes, Regulator
- Genetic Complementation Test
- Humans
- Molecular Sequence Data
- Mutation
- Recombinant Fusion Proteins
- Regulatory Factor X Transcription Factors