Article
Predictive value of interleukin-10 promoter genotypes and haplotypes in determining the susceptibility to nephropathy in type 2 diabetes patients.
Diabetes/metabolism research and reviews - 1 Jan 2009
Mtiraoui Nabil, Ezzidi Intissar, Kacem Maha, Ben Hadj Mohamed Manel, Chaieb Molka, Haj Jilani Aoutef Bel, Mahjoub Touhami, Almawi Wassim Y
Abstract excerpt
BACKGROUND: The IL-10 promoter polymorphisms -1082G/A, -819C/T, and -592C/A have been consistently associated with type 2 diabetes (T2DM). We examined whether these polymorphisms variants are also associated with progression of diabetic nephropathy (DN). METHODS: These promoter variants were genotyped in 917 T2DM patients comprising 515 DN patients and 402 control patients without nephropathy (DWN), together with...
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