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Article

Exploring the Prognostic Significance of IL10 Variants and Their Mechanistic Regulation in Diabetic Nephropathy.

Journal of cellular and molecular medicine - 1 Sept 2025

Shukla Neha, Kumari Shivani, Verma Poornima, Srivastava Amisha, Singh Neelam, Rao Gyan Manjary, Prasad Narayan, Gupta Sushil, Srivastava Anshika, Ansari M S, Janakiraman Soorya, Baden Marey, Wolkenhauer Olaf, Gupta Shailendra K, Gautam Naveen Kumar

Abstract excerpt

IL10 is a very effective anti-inflammatory cytokine. IL10 imbalance is linked to type 2 diabetes mellitus (T2DM) and also to renal hypertrophy, glomerular membrane thickening, and onset of diabetic nephropathy (DN). We aimed to investigate the association of IL10 gene polymorphism (rs1800871T/C, rs1800896A/G) with DN and determine the influence of variants on its expression level and interaction with...

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Identifiers

PMID: 40936203
DOI: 10.1111/jcmm.70819
PMCID: PMC12425813

Genes

IL10
KLF4
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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