Article
Interleukin-10-592C/A, -819C/T and -1082A/G promoter variants affect the susceptibility to nephropathy in Tunisian type 2 diabetes (T2DM) patients.
Clinical endocrinology - 1 Mar 2009
Ezzidi Intissar, Mtiraoui Nabil, Kacem Maha, Mallat Samir G, Mohamed Manel Ben Hadj, Chaieb Molka, Mahjoub Touhami, Almawi Wassim Y
Abstract excerpt
BACKGROUND: The Interleukin (IL)-10 polymorphic variants -1082G/A, -819C/T and -592C/A were linked with obesity, metabolic syndrome, and type 2 diabetes (T2DM). We investigated the hypothesis that IL-10 promoter polymorphisms may be associated with the progression of diabetic nephropathy (DN). DESIGN: Case-controlled study. PATIENTS: Study subjects comprised of 515 DN patients, and 402 normoalbuminuric (DWN) T2DM...
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