Article
Interleukin 1-beta gene polymorphisms and risk of gastric cancer in Sweden.
Scandinavian journal of gastroenterology - 1 Jan 2009
Persson Christina, Engstrand Lars, Nyrén Olof, Hansson Lars-Erik, Enroth Helena, Ekström Anna-Mia, Ye Weimin
Abstract excerpt
OBJECTIVE: Helicobacter pylori (H. pylori) infection stimulates the production of interleukin (IL)-1 beta, a pro-inflammatory cytokine and suppressor of gastric acid secretion. As both inflammation and hypochlorhydria, which might facilitate proximal colonization of H. pylori and other bacterial species alike, have been implicated in gastric carcinogenesis, much attention has been directed to functional genetic...
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