Article
Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer.
Immunology letters - 15 Sept 2005
Hellmig Stephan, Titz Andrea, Steinel Stefanie, Ott Stephan, Fölsch Ulrich Robert, Hampe Jochen, Schreiber Stefan
Abstract excerpt
BACKGROUND AND AIMS: Chronic H. pylori infection is the main cause of ulcer disease which depicts a major burden of our healthy care systems. The individual host immune response plays a pivotal role in the outcome of the infection but genetic susceptibility to develop gastric ulcer is unknown. IL-1beta and its natural receptor antagonist IL-1ra are involved in the inflammatory response to H. pylori infection....
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