Article
Estrogen receptor 1 gene polymorphisms in premenopausal women: interaction between genotype and smoking on lipid levels.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Oct 2008
Almeida S, Hutz M H
Abstract excerpt
Estrogen has multiple effects on lipid and lipoprotein metabolism. We investigated the association between the four common single nucleotide polymorphisms in the estrogen receptor 1 (ESR1) gene locus, -1989T>G, +261G>C, IVS1-397T>C and IVS1-351A>G, and lipid and lipoprotein levels in southern Brazilians. The sample consisted in 150 men and 187 premenopausal women. The women were considered premenopausal if they...
Topics
- Adult
- Estrogen Receptor alpha
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Lipids
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
