Article
Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level.
Human molecular genetics - 15 Aug 2005
Shearman Amanda M, Demissie Serkalem, Cupples L Adrienne, Peter Inga, Schmid Christopher H, Ordovas Jose M, Mendelsohn Michael E, Housman David E
Abstract excerpt
High levels of small low density lipoprotein (LDL) particles are a major risk factor for cardiovascular morbidity and mortality. Both estrogens and smoking, with known anti-estrogenic effects, alter the atherogenic lipid profile. We tested for a role of interaction between smoking and estrogen receptor alpha gene (ESR1) variation in association with plasma concentration of atherogenic small LDL particles and LDL...
Topics
- Estrogen Receptor alpha
- Female
- Genetic Variation
- Genotype
- Humans
- Lipoproteins, LDL
- Male
- Middle Aged
- Risk Factors
- Smoking