Article
Cardiorespiratory anomalies in mice lacking CB1 cannabinoid receptors.
PloS one - 1 Jan 2014
Silvani Alessandro, Berteotti Chiara, Bastianini Stefano, Cohen Gary, Lo Martire Viviana, Mazza Roberta, Pagotto Uberto, Quarta Carmelo, Zoccoli Giovanna
Abstract excerpt
Cannabinoid type 1 (CB1) receptors are expressed in the nervous and cardiovascular systems. In mice, CB1 receptor deficiency protects from metabolic consequences of a high-fat diet (HFD), increases sympathetic activity to brown fat, and entails sleep anomalies. We investigated whether sleep-wake and diet-dependent cardiorespiratory control is altered in mice lacking CB1 receptors. CB1 receptor knock-out (KO) and...
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