The mycobacteriophage D29 gene 65 encodes an early-expressed protein that functions as a structure-specific nuclease.

doi:10.1128/JB.00960-08

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Article

The mycobacteriophage D29 gene 65 encodes an early-expressed protein that functions as a structure-specific nuclease.

Journal of bacteriology - 1 Feb 2009

Giri Nabanita, Bhowmik Priyanka, Bhattacharya Bidisha, Mitra Mahashweta, Das Gupta Sujoy K

Abstract excerpt

The genomes of mycobacteriophages of the L5 family, which includes the lytic phage D29, contain several genes putatively linked to DNA synthesis. One such gene is 65, which encodes a protein belonging to the RecA/DnaB helicase superfamily. In this study a recombinant version of the mycobacteriophage D29 gp65 was functionally characterized. The results indicated that it is not a helicase as predicted but an...

Topics

Amino Acid Sequence
DNA, Viral
Exonucleases
Genome, Viral
Molecular Sequence Data
Mutation
Mycobacteriophages
Nucleic Acid Conformation
Recombinant Proteins
Sequence Homology, Amino Acid
Viral Proteins

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Identifiers

PMID: 19028888
DOI: 10.1128/JB.00960-08
PMCID: PMC2632071

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