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Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase.

The Journal of biological chemistry - 23 Jan 2009

Bakker Hans, Oka Takuji, Ashikov Angel, Yadav Ajit, Berger Monika, Rana Nadia A, Bai Xiaomei, Jigami Yoshifumi, Haltiwanger Robert S, Esko Jeffrey D, Gerardy-Schahn Rita

Abstract excerpt

In mammals, xylose is found as the first sugar residue of the tetrasaccharide GlcAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser, initiating the formation of the glycosaminoglycans heparin/heparan sulfate and chondroitin/dermatan sulfate. It is also found in the trisaccharide Xylalpha1-3Xylalpha1-3Glcbeta1-O-Ser on epidermal growth factor repeats of proteins, such as Notch. UDP-xylose synthase (UXS), which catalyzes...

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PMID: 19028698
DOI: 10.1074/jbc.M804394200
PMCID: PMC2629108

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