Article
Man o' war mutation in UDP-α-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation.
Biochemistry - 27 Jan 2015
Walsh Richard M, Polizzi Samuel J, Kadirvelraj Renuka, Howard Wesley W, Wood Zachary A
Abstract excerpt
The man o' war (mow) phenotype in zebrafish is characterized by severe craniofacial defects due to a missense mutation in UDP-α-d-xylose synthase (UXS), an essential enzyme in proteoglycan biosynthesis. The mow mutation is located in the UXS dimer interface ∼16 Å away from the active site, suggesting an indirect effect on the enzyme mechanism. We have examined the structural and catalytic consequences of the mow...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.