Article
ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis.
Thrombosis and haemostasis - 5 Jan 2017
Geys Lotte, Bauters Dries, Roose Elien, Tersteeg Claudia, Vanhoorelbeke Karen, Hoylaerts Marc F, Lijnen Roger H, Scroyen Ilse
Abstract excerpt
ADAMTS13 cleaves ultralarge multimeric von Willebrand Factor (VWF), thereby preventing formation of platelet-rich microthrombi. ADAMTS13 is mainly produced by hepatic stellate cells, and numerous studies have suggested a functional role of ADAMTS13 in the pathogenesis of liver diseases. The aim of our study was to investigate a potential role of ADAMTS13 in formation of hepatic microthrombi and development of...
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