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Article

The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesity

5 Jun 2025

Abstract excerpt

White adipose tissue (WAT) fibrosis occurring in obesity contributes to the inflammatory and metabolic comorbidities of insulin resistance and type 2 diabetes, yet the mechanisms involved remain poorly understood. Here, we report a role for the broadly conserved miRNA miR-30a as a regulator of WAT fibrosis and systemic glucose metabolism. Mice modified to express miR-30a at elevated levels in adipose tissues...

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Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Adipose Tissue and Metabolism
Share to Cardiovascular Disease and Adiposity

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PMID: 40471675
DOI: 10.1172/jci175566

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