Article
Association studies of the IL-23R gene in autoimmune thyroid disease in the Japanese population.
Autoimmunity - 1 Feb 2009
Ban Yoshiyuki, Tozaki Teruaki, Taniyama Matsuo, Nakano Yasuko, Yoneyama Kei-Ichiro, Ban Yoshio, Hirano Tsutomu
Abstract excerpt
Autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), are caused by interplays of genetic factors and environmental triggers. Interleukin-23 and its receptor (IL-23R) guide T cells towards the Th17 phenotype. IL-23R single nucleotide polymorphisms (SNPs) have been shown to be associated with several autoimmune diseases, including Crohn's disease and rheumatoid...
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