Overcoming P‐Glycoprotein‐Mediated Multidrug Resistance in Colorectal Cancer: Potential Reversal Agents among Herbal Medicines

Abstract excerpt

Objectives. Multidrug resistance (MDR) is the major reason for the failure of chemotherapy in colorectal cancer (CRC), and the primary determinant of MDR in CRC patients is active drug efflux owing to overexpression of P‐glycoprotein (P‐gp) in cancer tissues. Despite research efforts to overcome P‐gp‐mediated drug efflux, the high toxicity of P‐gp inhibitors has been a major obstacle for the clinical use of these...

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