Article
Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML.
Leukemia - 1 Feb 2009
Hollink I H I M, Zwaan C M, Zimmermann M, Arentsen-Peters T C J M, Pieters R, Cloos J, Kaspers G J L, de Graaf S S N, Harbott J, Creutzig U, Reinhardt D, van den Heuvel-Eibrink M M, Thiede C
Abstract excerpt
Nucleophosmin (NPM1) mutations occur frequently in adult cytogenetically normal acute myeloid leukemia (CN-AML) and confer favorable outcome. We investigated the frequency and prognostic significance of NPM1 mutations in childhood AML (n=298), specifically focusing on the CN-AML subgroup (n=100). Mutations were found in 8.4%, and clustered significantly in the CN-AML subgroup (22%). No mutations were found in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.