Transcription of the RelB gene is regulated by NF-kappaB.

doi:10.1038/sj.onc.1204868

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Article

Transcription of the RelB gene is regulated by NF-kappaB.

Oncogene - 22 Nov 2001

Bren G D, Solan N J, Miyoshi H, Pennington K N, Pobst L J, Paya C V

Abstract excerpt

RelA and RelB are two members of the NF-kappaB family that differ structurally and functionally. While RelA is regulated through its cytosolic localization by inhibitor proteins or IkappaB and not through transcriptional mechanisms, the regulation of RelB is poorly understood. In this study we demonstrate that stimuli (TNF or LPS) lead within minutes to the nuclear translocation of RelA, but require hours to...

Topics

5' Untranslated Regions
Animals
Base Sequence
Cell Nucleus
Cloning, Molecular
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Electrophoretic Mobility Shift Assay
Enhancer Elements, Genetic
HeLa Cells
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Jurkat Cells

Mice

Molecular Sequence Data

Mutation

NF-kappa B

Promoter Regions, Genetic

Protein Transport

Source

Open in PubMed

Identifiers

PMID: 11753650
DOI: 10.1038/sj.onc.1204868

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