Article
Transcription of the RelB gene is regulated by NF-kappaB.
Oncogene - 22 Nov 2001
Bren G D, Solan N J, Miyoshi H, Pennington K N, Pobst L J, Paya C V
Abstract excerpt
RelA and RelB are two members of the NF-kappaB family that differ structurally and functionally. While RelA is regulated through its cytosolic localization by inhibitor proteins or IkappaB and not through transcriptional mechanisms, the regulation of RelB is poorly understood. In this study we demonstrate that stimuli (TNF or LPS) lead within minutes to the nuclear translocation of RelA, but require hours to...
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