Article
Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype.
Pharmacogenomics - 1 Nov 2008
Hayashida Masakazu, Nagashima Makoto, Satoh Yasuo, Katoh Ryoji, Tagami Megumi, Ide Soichiro, Kasai Shinya, Nishizawa Daisuke, Ogai Yasukazu, Hasegawa Junko, Komatsu Hiroshi, Sora Ichiro, Fukuda Kenichi, Koga Hisashi, Hanaoka Kazuo, Ikeda Kazutaka
Abstract excerpt
AIMS: The association between SNPs of the human OPRM1 gene encoding the micro-opioid receptor and postoperative analgesic requirements in surgical patients remains controversial. Here, we evaluate whether any of the five tag SNPs (A118G, IVS2+G691C, IVS3+G5953A, IVS3+A8449G and TAA+A2109G) representing the four linkage disequilibrium blocks of the OPRM1 gene influences postoperative analgesic requirements....
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