Article
Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy.
Pharmacogenomics - 1 Jan 2018
Nishizawa Daisuke, Mieda Tsutomu, Tsujita Miki, Nakagawa Hideyuki, Yamaguchi Shigeki, Kasai Shinya, Hasegawa Junko, Fukuda Ken-Ichi, Kitamura Akira, Hayashida Masakazu, Ikeda Kazutaka
Abstract excerpt
AIM: Opioids are widely used as effective analgesics, but opioid sensitivity is well known to vary widely among individuals. We explored the genetic factors that contribute to individual differences in intraoperative opioid sensitivity by performing a genome-wide association study. PATIENTS & METHODS: We conducted a multistage genome-wide association study in subjects who underwent laparoscopic-assisted...
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